|
KMID : 1202020140070020172
|
|
Journal of Korean Thyroid Association
2014 Volume.7 No. 2 p.172 ~ p.179
|
|
|
Effect of Short-Term Hypothyroid State on Lipid Profile andCardiovascular Risk Markers in Subjects Preparing RadioactiveIodine Therapy
|
|
Yeo Hye-Ju
Jo A-Ra
Lee Hye-Won
Lee Dong-Won
Kang Yang-Ho
Son Suk-Man
|
|
|
Abstract
|
|
|
Background and Objectives: The relationship between short-term hypothyroidism due to levothyroxine (LT4)withdrawal for radioactive iodine (RI) therapy in patients with differentiated thyroid cancer (DTC) and risk ofcardiovascular disease is not clear. In this study, we evaluated the impact of short-term overt hypothyroidismon lipid profiles and cardiovascular parameters in patients with DTC.
Materials and Methods: We recruited 195patients with DTC who were preparing RI therapy from March 2008 to February 2012. We analyzed the effectof thyroid stimulating hormone (TSH) level on the clinical, biochemical, and cardiovascular risk markers at theend of LT4 withdrawal protocol (P2).
Results: After LT4 withdrawal (P2), TSH and total cholesterol (TC) levels weresignificantly increased (p＜0.005). After adjustment for multiple factors such as age, sex, body mass index (BMI),hypertension and diabetes mellitus (DM), the positive relationship between TSH and TC remained significant(p=0.04). Mean levels of homocysteine, low density lipoprotein-cholesterol, triglyceride were increased.However, levels of high density lipoprotein-cholesterol, cystatin C, C-reactive protein, apolipoprotein B (ApoB),apolipoprotein A1 (Apo A1), lipoprotein (a) (Lp[a]), aspartate transaminase, alanine aminotransferase, totalbilirubin, uric acid remained within normal range. Splitting the whole cohort into the three different age groups,serum Apo B, Lp(a) levels and BMI increased with increasing age (p＜0.05). And splitting into three differentTSH level groups (1st group; ＜79 μIU/mL, 2nd group; 79-121 μIU/mL, 3rd group; ＞121 μIU/mL), all values didnot have a statistical significant meaning except Apo A1.
Conclusion: Short-term hypothyroidism inducedworsening of lipid metabolic parameters, but not enough to induce the cardiovascular risk in patients withthyroid cancer.
|
|
|
KEYWORD
|
|
|
Short-term hypothyroidism, Thyroid cancer, Cardiovascular risk markers, Radioactive iodine therapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|